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This information does not take the place of talking to your healthcare provider about either your medical condition or your treatment with ACTEMRA. Talk with your healthcare provider if you have any questions about your treatment with ACTEMRA.


ACTEMRA is a prescription medicine called an interleukin-6 (IL-6) receptor inhibitor.


Some people have serious infections while taking ACTEMRA, including tuberculosis (TB), and infections caused by bacteria, fungi or viruses that can spread throughout the body. Some people have died from these infections.

Other serious side effects of ACTEMRA include tears (perforation) of the stomach and intestines, changes in blood test results, (including low neutrophil count, low platelet count, increase in certain liver function tests and increase in blood cholesterol levels), hepatitis B infection becoming an active infection again and nervous system problems.

ACTEMRA affects the immune system and may increase your risk of certain cancers.

Serious allergic reactions, including death, can happen with ACTEMRA. These reactions may happen with any infusion of ACTEMRA, even if they did not occur with an earlier infusion. Patients must tell their doctor if they have had a previous reaction to ACTEMRA. Patients should not take ACTEMRA if they are allergic to it or any of its ingredients.

Common side effects with ACTEMRA in patients with RA include upper respiratory tract infections (common cold, sinus infections), headache and increased blood pressure (hypertension).

Common side effects with ACTEMRA in patients with SJIA include upper respiratory tract infections (common cold, sinus infections), headache and diarrhea.

Patients must tell their healthcare providers if they plan to become pregnant or are pregnant. It is not known if ACTEMRA will harm an unborn baby. Genentech has a registry for pregnant women who take ACTEMRA. Patients who are pregnant or become pregnant while taking ACTEMRA must contact the registry at 1-877-311-8972 and talk to their healthcare provider.

Patients must call their healthcare provider for medical advice about any side effects. You may report side effects to the FDA at (800) FDA-1088 or You may also report side effects to Genentech at (888) 835-2555.

For additional important safety information, including Boxed Warning and Medication Guide, please visit or call (800) ACTEMRA (800-228-3672).